- Է : 2021-03-02 05:45
- | ü ȿ ռ â ӻ
- | о ̹ ü NASH 3 ָ
|ĮŸ=κ | ۷ī Ÿ̵-1(GLP-1) 迭 索 ġ ۷Ÿ̵() â ӻ յ ϸ ݼ 氣(NASH) Ȯ忡 ִ.
Ư о߿ ϰ ִ ۷Ÿ̵(輾) Ѿ ȿ ̸ ƿ 븦 ִµ ġ NASH Ҹ ӻ ̰ ִٴ 3տ 밨 ̰ ִ.
۷Ÿ̵ â о
۷Ÿ̵尡 ָ ޱ ֻ GLP-1 Ѱ踦 Ѿ ù 汸 õϸ鼭ʹ.
GLP-1 ״索 ȿ ֻ Ʋ ذϸ鼭 GLP-1 ο ָ ̴.
GLP-1 ȿ ߴ. 索 Ը ӻ 'PIONEER' 'SUSTAIN' ø ȣ DPP-4 SGLT-2 , GLP-1 еϸ ȿ ̴.
汸, ֻ GLP-1 ŸƲ ȿ θ 䳢 鼭 索 ġ 忡 ٶ .
PIONEER-2 ۷Ÿ̵ 索 SGLT-2i ı۸÷(ڵ) ӻ 26° ȭ 1.3% ϸ ı۸÷ 0.9% Ѿ.
SUSTAIN . ӻ ī۸÷(κī) ȿ ߸Ͱ ӻ .
ӻ ۷Ÿ̵ 52° ȭ 1.5% ҽ ī۷ 1.0% еߴ. 2 ǥ ȭ 鿡 ۷Ÿ̵带 ȯڴ 66.1% ī۸÷ 45.1% ȴ.
GLP-1 迭 ϰ ߴ. ۷Ÿ̵ ӻ 30° ȭ ҷ 1.7% ۷Ÿ̵ 1% ߴ .
̷ ۷Ÿ̵ 索 忡 ٶ 븦 Ҵ. 뺸ũ ο Ѵ. 'PIONEER' 'SUSTAIN' ӻ ø ü ȿ Ÿ Ϳ ָ ̴.
ӻ 3 15% ü ȿ 輾 ü
Ը ӻ ø PIONEER-2 ۷Ÿ̵ ġ 52° 4.7kg ü ȿ ̸ ɼ ߴ.
۷Ÿ̵尡 ӻ 3 15% ü ȿ ̸ ü ָް ִ.
SUSTAIN ӻ . ӻ ۷Ÿ̵ 52° 5kg ̻(-5.3kg, -5.1kg, -5.0kg) ü ȿ ̸鼭 ָҴ.
뺸ũ â ͵ ̷ ̴. ᱹ 索 踦 ѵ 1븦 Ѿ ̶ ħ 긮 ߴ.
ӻ ٰſ. ü ȿ Ը ӻ ־ ̴ 索 ȿ ӻ, ɼ ٰŷ .
̷ 2 ױ۷ (NEJM) ħ Ÿ ϴ ۷Ÿ̵ 3 ӻ Ǹ鼭 ū ȭ ִ.
ݱ ٵ ȿ ̸ κ 'ü' Īȣ ̴.
ӻ (10.1056/NEJMoa2032183) ̿ ٰŴ ģ. ϴ ̹ ӻ 16 1961 ȯڸ Ͱ ƴ.
1 ǥ 68° ü ȿ м ۷Ÿ̵ 14.9% ȿ . 2.4% Ұߴٴ ϸ ġ.
1 ǥ ü 5% ̻ ߴ. ۷Ÿ̵带 ó ȯڵ 86.4% 68ֱ 5% ̻ ü ҵ ¸ ̴. ü 10% ̻ · ȯڵ鵵 69.1% ߴ.
̿ 뺸ũ ̷ ӻ ̱ ǰǾ౹(FDA) Ӱ û ´. ݱ⳻ Ǿǰû(EMA) ̸ û ̴.
̷ ӻ ۷Ÿ̵ 輾ٸ ǰ ź ϰ ִ.
ǻ 輾ٿ ۷Ÿ̵ ƿ . 索 ߵ ġ ް ִ ͵ ϸ 絵 .
常 輾ٴ ظ 368 (ť ) ø ε 1 ϰ ִ. ťù̾ ٽ ڸ Ѱ ̴ ִ.
۷Ÿ̵尡 õǸ 輾 ̾ ÿ ž ȿ ̶ ִ ͵ ̷ ̴.
Դٰ ۷Ÿ̵ 1ȸ 輾 ۷Ÿ̵ 1ȸ ټ 鿡 ִٴ 밨 ̴ ϳ.
䱸 Ѻȸ ӿ "ݱ ڸ ü ϳ ٴ ӻ ȿθ ٸ е ̶ ִ" "Դٰ 索 Ŀ ϴٴ 輾 ״ ̾Ұ ӿ ִٴ ϴ" ߴ.
̾ ״ "̹ 뺸 ڿ ü ۾ ˰ ִ" " ״ ӻ ӻ 嵥 ѹ ʿϴٴ θ Ǵϱ ̸ٰ " ٿ.
Ѿ NASH ô ס
۷Ÿ̵ ʰ ִ. ü ȿ پ о߷ 븮 ִ .
ݼ 氣(NASH) о߰ ǥ . ᱹ ݼ 氣 ü ߿ ӻ ǥ о߷ â ø ִ ̴.
̿ ӻ Ҹ ̴. ̱ȸ(AASLD) 2 ӻ ǥ .
17 ݼ 氣 ȯ 320 Ͱ ӻ ۷Ÿ̵ ִ 60% NASH ҽǽ״.
ü 0.1mg ó ȯڴ 1 72° 40.4% ȯڰ ݼ 氣 ҽǵƴ.
0.2mg 35.6% ҽǵǴ 0.4mg 58.9% ȯڵ ȭ ݼ 氣 .
索 ߵ ָް ִ ŭ ̿ ΰ ȿ鵵 иߴ.
ȯڵ鿡Լ 12.5% ü ȿ Ÿ ȭҵ 1.5% ҽ״. 索 ִ ݼ 氣 ȯڳ ݼ 氣 Բ ִ ȯڿ ɼ ִٴ ǹѴ.
̷ ӻ Ǹ鼭 鵵 밨 ̰ ִ. ǻ ݼ 氣 ѷ ġ ٴ 밨 Ȳ.
Ѱȸ 9 ݼ 氣 ̵ غϸ鼭 ۷Ÿ̵带 鿡 ͵ ̿ ʴ.
ȸ 5 ǥǴ ̵ ǿ ۷Ÿ̵带 ǻ ֿ켱 ǰߴ. 3 Ȳ ̵ο ̸ øٴ ſ . ŭ Ŵ 밡 ٴ ǹѴ.
Ǵ ȭ⳻ "۷Ÿ̵尡 ü ȿ ݼ 氣 ġῡ ȿ ̰ ִ" "2 ӻ 0.1mg 뷮ε 40% ҽǷ Ҹ ϴٴ Ǵ ̵ο ߴ" ߴ.
״ ̾ " ۷Ÿ̵尡 Ȳ̶ ٰ ߽ ̵ ۾ غ ִ" ߴ.